Chemical and Pharmaceutical Bulletin
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Concise and Versatile Synthesis of Sulfoquinovosyl Acyl Glycerol Derivatives for Biological Applications
Tomohiro Tanaka, Yasuhiro Sawamoto, Shin Aoki
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Volume 65 (2017) Issue 6 Pages 566-572

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Abstract

Sulfoquinovosyl acylpropanediol (SQAP), a chemically modified analogue of sulfoquinovosyl acylglycerol (SQAG) that occurs in sea algae, has been reported to show a variety of biological activities, including accumulation in tumor cells and the inhibition of tumor cell growth. We report herein on a new concise and versatile synthesis of SQAP itself and derivatives bearing iodoaryl groups and boronclusters. This method should be useful for the design and synthesis of SQAG/SQAP derivatives for diagnosis and the treatment of cancer and related diseases.

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Copyright © 2017 The Pharmaceutical Society of Japan
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