Chemical and Pharmaceutical Bulletin
Advance online publication
Advance online publication

This service provides final online versions of articles before they are compiled and published in an issue. These versions comprise full-text, peer-reviewed, accepted articles as soon as they are ready for publication, before the release of the compiled print issue, and have DOIs.

Showing 1-7 articles out of 7 articles from Advance online publication
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  • Jie Li, Tu-cai Zheng, Yi Jin, Jian-guo Xu, Jian-gang Yu, Yan-wen Lv
    Article ID: c17-00035
    [Advance publication] Released: November 09, 2017
    JOURNALS PEER REVIEWED FREE ACCESS ADVANCE PUBLICATION

    A series of novel quinolone derivatives (8a-j) were synthesized, and their anticancer activities were tested in human cancer cell lines A549, HL-60, and Hela. Compound 8i was found to be 5-times more potent in cell-killing activity for cell lines A549, HL-60, and Hela than the positive control irinotecan or cisplatin, with IC50 of 0.009, 0.008 and 0.010 μM, respectively. The docking study revealed that compound 8i might have strong interactions with the active site of DNA-Topoisomerase I.

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  • San-qing Lin, Zhong-liu Zhou, Chun-Yan Li
    Article ID: c17-00608
    [Advance publication] Released: November 09, 2017
    JOURNALS PEER REVIEWED FREE ACCESS ADVANCE PUBLICATION

    Cyprotuoside C (1) and cyprotuoside D (2), two new cycloartane glycosides were isolated from the ethanol extract of the rhizomes of Cyperus rotundus. Their structures were identified as 24R-9, 10-seco-cycloartan-1 (10), 9 (11)-dien-3β, 7β, 24, 25-tetraol 3-O-β-D-xylopyranosyl-(1→4)-[α-L-arabinopyranosyl-(1→6)]-β-D-glucopyranosyl-25-O-β-D-glucuronide (1) and 9, 10-seco-cycloartan-1 (10), 9 (11), 23 (24)-trien-3β, 7β, 25-triol 3-O-β-D-xylopyranosyl-(1→4)-{α-L-arabinopyranosyl-(1→6)-[ α-L-rhamnopyranosyl-(1→2)-]}-β-D-glucopyranosyl-25-O-β-D-glucuronide (2) by spectroscopic methods.

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  • Bancha Yingngam, Adelheid H. Brantner, Damrongsak Jinarat, Rawiwun Kaewamatawong, Wandee Rungseevijitprapa ...
    Article ID: c17-00517
    [Advance publication] Released: October 26, 2017
    JOURNALS PEER REVIEWED FREE ACCESS ADVANCE PUBLICATION

    A method for quantification of diarylheptanoids in Curcuma comosa rhizomes and selected pharmaceutical preparations was established by using HPLC-DAD. The chromatographic separation of three diarylheptanoids [(3S)-1-(3,4-dihydroxy-phenyl)-7-phenyl-(6E)-6-hepten-3-ol (1), (3R)-1,7-diphenyl-(4E,6E)-4,6-heptadien-3-ol (2), and (3S)-1,7-diphenyl-(6E)-6-hepten-3-ol (3)] was performed on a Luna C18 analytical column using gradient elution with 0.5% acetic acid in water and acetonitrile with a flow rate of 1 mL/min and a column temperature of 35 °C. The calibration curves for the analytes showed good linearity (R2 > 0.999), high precision (RSD < 2%) and acceptable recovery (98.35–103.90%, RSD < 2%). The limit of detection (LOD) and limit of quantification (LOQ) were 0.06–0.22 and 0.18–0.69 µg/mL, respectively. The results of all validated parameters were within the limits according to the International Conference on Harmonization (ICH) Guidelines. The established method was successfully applied for qualitative and quantitative determination of the three constituents in different samples of C. comosa and some commercial products in capsules. The simplicity, rapidity, and reliability of the method could be useful for the fingerprint analysis and standardization of diarylheptanoids, which are responsible for the estrogenic activity in raw materials and herbal medicinal products of C. comosa.

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  • Herman Palacio, Felipe Otálvaro, Luis F. Giraldo, Gilles Ponchel, Freimar Segura-Sánchez ...
    Article ID: c17-00624
    [Advance publication] Released: October 12, 2017
    JOURNALS PEER REVIEWED FREE ACCESS ADVANCE PUBLICATION

    Drug delivery represents one of the most important research fields within the pharmaceutical industry. Different strategies are reported every day in a dynamic search for carriers with the ability to transport drugs across the body, avoiding or decreasing toxic issues and improving therapeutic activity. One of the most interesting strategies currently under research is the development of drug delivery systems sensitive to different stimuli, due to the high potential attributed to the selective delivery of the payload. In this work, a stimuli-sensitive nanocarrier was built with a bifunctional acrylic polymer, linked by imine and disulfide bonds to thiolate chitosan, the latter being a biopolymer widely known in the field of tissue engineering and drug delivery by its biodegradability and biocompatibility. These polymer nanoparticles were exposed to different changes in pH and redox potential, which are environments commonly found inside cancer cells. The results proof the ability of the nanoparticles to keep the original structure when either changes in pH or redox potential were applied individually. However, when both stimuli were applied simultaneously, a disassembly of the nanoparticles was evident. These special characteristics make these nanoparticles suitable nanocarriers with potential for the selective delivery of anticancer drugs.

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  • Yuki Sakai, Yukiko Asakura, Mitsuhiro Morita, Takashi Takahashi
    Article ID: c17-00637
    [Advance publication] Released: September 27, 2017
    JOURNALS PEER REVIEWED FREE ACCESS ADVANCE PUBLICATION

    Hydroxy β-methyl fatty acid ethyl esters bearing different carbon chain lengths and varying hydroxyl group positions were successfully synthesized from symmetric diols. These fatty acid derivatives are useful intermediates of chemical probes for metabolic analyses of fatty acid.

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  • Tae In Kim, Bora Shin, Geum Jin Kim, Hyukjae Choi, Chong Soon Lee, Mi Hee Woo, Dong-Chan Oh ...
    Article ID: c17-00466
    [Advance publication] Released: September 26, 2017
    JOURNALS PEER REVIEWED FREE ACCESS ADVANCE PUBLICATION

    Three new compounds, a sesquilignan (1) and two glucosylated phenylpropanoids (2, 3), and seven known compounds (4-10), were isolated from the fruits of Illicium verum Hook. Fil. (Illiciaceae). The structures of 1-3 were determined based on one and two dimensional (1D- and 2D-) NMR data and ECD spectra analyses. Compounds 3, 5, 6, and 8-10 exhibited potent inhibitory activities against topoisomerase II with IC50 values of 54.6, 25.5, 17.9, 12.1, 0.3 and 1.0 μM, respectively, compared to etoposide, the positive control, with an IC50 of 43.8 μM.

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  • Kouhei Ishizawa, Hideoki Nagai, Yohei Shimizu, Motomu Kanai
    Article ID: c17-00545
    [Advance publication] Released: August 19, 2017
    JOURNALS PEER REVIEWED FREE ACCESS ADVANCE PUBLICATION

    A catalytic carboxylic acid-selective aldol reaction with trifluoromethyl ketones was developed. Reversible and selective covalent bond formation between a boron catalyst and a carboxylic acid is key to realizing the unprecedented catalytic aldol reaction of simple carboxylic acids. The reaction proceeded chemoselectively at the α-position of carboxylic acid even in the presence of ketone, ester, or amide functional groups in the donor substrates. The chemoselectivity is beneficial for late-stage derivatizations of biologically relevant compounds, as demonstrated by the conversion of indomethacin and triacetylcholic acid.

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